New Books Purchased by Campbell Library
by Daniel Kipnis on 2021-04-07T13:40:59-04:00 | 0 Comments
Food Chains, Yields, Models, and Management of Large Marine Ecosoystems by
ISBN: 9780429695254
Publication Date: 2019-05-20
Draws on case studies from tropical, temperate, and Arctic waters around the world, comparing multispecies biomass yield models for various large marine ecosystems. Emphasis is given to adaptive management as a strategy for maximizing the sustainability and productivity of living marine resources.
Quantitative Analyses in Wildlife Science by
ISBN: 1421431076
Publication Date: 2019-09-10
Over the past fifty years, wildlife science has become increasingly quantitative. But to wildlife scientists, many of whom have not been formally trained as biometricians, computer modelers, or mathematicians, the wide array of available techniques for analyzing wildlife populations and habitats can be overwhelming. This practical book aims to help students and professionals alike understand how to use quantitative methods to inform their work in the field. Covering the most widely used contemporary approaches to the analysis of wildlife populations and habitats, Quantitative Analyses in Wildlife Science is divided into five broad areas: * general statistical methods * demographic estimation * dynamic process modeling * analysis of spatially based data on animals and resources * numerical methods Addressing a variety of topics, from population estimation and growth trend predictions to the study of migration patterns, this book presents fresh data on such pressing issues as sustainable take, control of invasives, and species reintroduction. Authored by leading researchers in wildlife science, each chapter considers the structure of data in relation to a particular analytical technique, as well as the structure of variation in those data. Providing conceptual and quantitative overviews of modern analytical methods, the techniques covered in this book also apply to conservation research and wildlife policy. Whether a quick refresher or a comprehensive introduction is called for, Quantitative Analyses in Wildlife Science is an indispensable addition to every wildlife professional's bookshelf. Contributors: William M. Block, Leonard A. Brennan, Stephen T. Buckland, Christopher C. Chizinski, Evan C. Cooch, Raymond J. Davis, Stephen J. DeMaso, Randy W. DeYoung, Jane Elith, Joseph J. Fontane, Julie A. Heinrichs, Mevin B. Hooten, Julianna M. A. Jenkins, Zachary S. Laden, Damon B. Lesmeister, Daniel Linden, Jeffrey J. Lusk, Bruce G. Marcot, David L. Miller, Michael L. Morrison, Eric Rexstad, Jamie S. Sanderlin, Joseph P. Sands, Erica F. Stuber, Chris Sutherland, Andrew N. Tri, David B. Wester, Gary C. White, Christopher K. Williams, Damon L. Williford
Trends in Biochemistry and Molecular Biology by
ISBN: 1536164356
Publication Date: 2019-10-25
"Trends in Biochemistry and Molecular Biology" provides the essential information necessary for students in the life and health sciences. The book adopts a readable, student-friendly style that helps introduce students to this fascinating and often-times daunting subject. Each chapter begins with a summary of essential facts followed by descriptions of the subjects that focus on core information with clear, simple diagrams that are easy for students to understand and recall in essays. The extensive use of cross-referencing makes it possible for students to return to individual sections for review purposes without difficulty. Whether students interests lie in biological, chemical, or medical aspects of biochemistry and molecular biology, "Trends Biochemistry and Molecular Biology" will help make students able, excited, and eager to read more widely and more deeply on this engaging subject. This important new book not only covers an extensive set of topics of current and special interest, but includes more traditional areas in biochemistry as well. Covering a wide range of topics, from classical biochemistry to proteomics and genomics, it also details the properties of commonly used biochemicals, laboratory solvents, and reagents. Coverage is expanded to include a section on stem cells, chapters on immunochemical techniques and spectroscopy techniques, and additional chapters on drug discovery and development, and clinical biochemistry. Moreover, a number of techniques used in molecular biology, for example, molecular cloning, gel electrophoresis, polymerase chain reaction, microarrays, etc. are also explained with practical examples. It also includes some of the vital pieces of work being conducted across the world, on various topics related to molecular biology. Through it, we attempt to further enlighten the readers about the new concepts in this field. Altogether, presented in an organized, concise, and simple-to-use format, "Trends in Biochemistry and Molecular Biology" allows quick access to the most frequently used data. There is an emphasis on biological aspects of biochemistry and new topics are introduced in their biological context wherever possible. Experimental design and the statistical analysis of data are emphasized at the end to ensure students are equipped to successfully plan their own experiments and examine the results obtained.
Multiomic Association Studies with Bioconductor by
ISBN: 1138340561
Publication Date: 2019-06-12
After the great expansion of genome-wide association studies, their scientific methodology and, notably, their data analysis has matured in recent years, and they are a keystone in large epidemiological studies. Newcomers to the field are confronted with a wealth of data, resources and methods. This book presents current methods to perform informative analyses using real and illustrative data with established bioinformatics tools and guides the reader through the use of publicly available data. Includes clear, readable programming codes for readers to reproduce and adapt to their own data. Emphasises extracting biologically meaningful associations between traits of interest and genomic, transcriptomic and epigenomic data Uses up-to-date methods to exploit omic data Presents methods through specific examples and computing sessions Supplemented by a website, including code, datasets, and solutions amp;lt;/P> Supplemented by a website, including code, datasets, and solutions
Handbook of Statistical Genomics by
ISBN: 1119429145
Publication Date: 2019-09-10
A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.
Practical Guide to Chip-Seq Data Analysis by
ISBN: 1138596523
Publication Date: 2018-11-02
Chromatin immunoprecipitation sequencing (ChIP-seq), which maps the genome-wide localization patterns of transcription factors and epigenetic marks, is among the most widely used methods in molecular biology. Practical Guide to ChIP-seq Data Analysis will guide readers through the steps of ChIP-seq analysis: from quality control, through peak calling, to downstream analyses. It will help experimental biologists to design their ChIP-seq experiments with the analysis in mind, and to perform the basic analysis steps themselves. It also aims to support bioinformaticians to understand how the data is generated, what the sources of biases are, and which methods are appropriate for different analyses.
CliffsNotes Biology Quick Review Third Edition by
ISBN: 9781328505941
Publication Date: 2019-05-14
A no-nonsense, quick review of biology for high school and college students CliffsNotes Biology Quick Review,3rd Edition, provides a clear, concise, easy-to-use review of biology basics. Perfect for high school and college students, teacher candidates taking the Praxis Biology test, and anyone wanting to brush up on their biology knowledge. Whether you're new to elements, atoms, and molecules or just wanting to refresh your understanding of the subject, this guide can help. Aligned to NGSS, it includes topics such as cellular respiration, photosynthesis, mitosis and cell reproduction, genetics, DNA, and plant and animal structures and functions. The target audience is high school and college students: 96% of high school students take a biology course before graduating, and biology "101" is a staple at all colleges and universities.
From Models to Simulations by
ISBN: 1138065218
Publication Date: 2018-09-07
This book analyses the impact computerization has had on contemporary science and explains the origins, technical nature and epistemological consequences of the current decisive interplay between technology and science: an intertwining of formalism, computation, data acquisition, data and visualization and how these factors have led to the spread of simulation models since the 1950s. Using historical, comparative and interpretative case studies from a range of disciplines, with a particular emphasis on the case of plant studies, the author shows how and why computers, data treatment devices and programming languages have occasioned a gradual but irresistible and massive shift from mathematical models to computer simulations.
Inside Science by
ISBN: 022661798X
Publication Date: 2019-02-27
Context and situation always matter in both human and animal lives. Unique insights can be gleaned from conducting scientific studies from within human communities and animal habitats. Inside Science is a novel treatment of this distinctive mode of fieldwork. Robert E. Kohler illuminates these resident practices through close analyses of classic studies: of Trobriand Islanders, Chicago hobos, corner boys in Boston's North End, Jane Goodall's chimpanzees of the Gombe Stream Reserve, and more. Intensive firsthand observation; a preference for generalizing from observed particulars, rather than from universal principles; and an ultimate framing of their results in narrative form characterize these inside stories from the field. Resident observing takes place across a range of sciences, from anthropology and sociology to primatology, wildlife ecology, and beyond. What makes it special, Kohler argues, is the direct access it affords scientists to the contexts in which their subjects live and act. These scientists understand their subjects not by keeping their distance but by living among them and engaging with them in ways large and small. This approach also demonstrates how science and everyday life--often assumed to be different and separate ways of knowing--are in fact overlapping aspects of the human experience. This story-driven exploration is perfect for historians, sociologists, and philosophers who want to know how scientists go about making robust knowledge of nature and society.
Nazis, Women and Molecular Biology by
ISBN: 9781138512511
Publication Date: 2018-02-12
What prompts a well-renowned scientist in molecular biology to write memoirs about a part of his life? In the case of Gunther Stent, it was not to reflect on his career as a scientist, but to come to an understanding of his own soul. In his seventies, he had come to see that he had been, throughout his life, an emotional sleepwalker, especially as regards women and, in addition, that he had been troubled by Jewish self-hatred. His story may have more to do with St. Augustine's Confessions than with a scientist's memoirs. Stent provides insight into the power of political correctness, and the ability of a government to establish a perverse vision of reality. For readers interested in bioethics, Stent's memoirs help to explain how Germany could have been the first country to enact an all-encompassing protection for human research subjects while it was also the country that produced the medical experiments of the Nazis and the greatest perversion of medical morality in history. Stent is a person of intelligence and subtlety, an accomplished writer, a deep and wise man, and a loyal friend. His narrative is centered emotionally on a youth spent in Berlin in the Nazi period. As a boy of fourteen he was an eyewitness of the horrors of the Kristallnacht pogrom.On New Year's Eve 1938 he escaped from Germany across the "green frontier." He came to America in his teens, only to return to Berlin at the end of World War II as a scientific consultant for the U.S. Military. On his return to the States, Stent participated in the exciting early scientific breakthroughs of molecular biology that transformed the twentieth-century life sciences. His Nazis, Women and Molecular Biology is a piercing self-examination, and as its review in Science Newsletter says, "an act of self-exposure, abnegation, contrition, and expiation." It will be of keen interest to those who have inhabited Stent's worlds or shared his experiences, as well as those who wish to learn more about them. Gunther S. Stent is professor emeritus of neurobiology at the University of California, Berkeley. He is the author of such classic texts as Molecular Biology of Bacterial Viruses and Molecular Genetics, as well as philosophical books, such as The Coming of the Golden Age, Paradoxes of Progress, and, most recently (2002), Paradoxes of Free Will.
Medical Bioinformatics and Biochemistry (Diabormatics) by
ISBN: 9781536149524
Publication Date: 2019-05-10
The first edition of Medical Bioinformatics and Biochemistry (Diabormatics) explains how medical biochemistry and bioinformatics could be used as a tool for analyzing the research data related to disease diagnosis and treatment. Bioinformatics is an interdisciplinary approach that includes concepts of biotechnology, microbiology, molecular biology, medicine and forensic science. This book is based on the recent development in the research dynamics of medical bioinformatics, biochemistry and progress in these fields. The book provides reference material for students of medical and life sciences. The development in genomic sequencing and in silico biology has provided the data needed to accomplish comparisons of derived nucleotide and protein sequences. The results of analysis may be used to formulate and test hypotheses about biochemical function. This first edition provides readers with a practical guide covering the full scope of concepts in medical bioinformatics and biochemistry related to diabetes. The basic purpose of this book is for students of medical and life sciences to understand the research methods of biochemistry and bioinformatics. This includes storing, receiving, and analyzing data from databases using various in silico tools. This book is a useful source of knowledge for MBBS, B.Sc, M.Sc / M.D. / M.S. and Ph.D level students looking for an accessible introduction to the subject.
Biomembrane Simulations by
ISBN: 1351060309
Publication Date: 2019-04-30
Due to recent advancements in the development of numerical algorithms and computational hardware, computer simulations of biological membranes, often requiring use of substantial computational resources, are now reaching a mature stage. Since molecular processes in membranes occur on a multitude of spatial and time scales, molecular simulations of membranes can also serve as a testing ground for use of multi-scale simulation techniques. This book addresses some of the important issues related to understanding properties and behavior of model biological membranes and it Shows how simulations improve our understanding of biological membranes and makes connections with experimental results. Presents a careful discussion of the force fields used in the membrane simulations including detailed all-atom fields and coarse-grained fields. Presents a continuum description of membranes. Discusses a variety of issues such as influence of membrane surfaces on properties of water, interaction between membranes across water, nanoparticle permeation across the membrane, action of anesthetics and creation of inhomogeneous regions in membranes. Discusses important methodological issues when using simulations to examine phenomena such as pore creation and permeation across membranes. Discusses progress recently achieved in modeling bacterial membranes. It will be a valuable resource for graduate students, researchers and instructors in biochemistry, biophysics, pharmacology, physiology, and computational biology.
Biodiversity and Conservation by
ISBN: 1771887486
Publication Date: 2019-04-16
This volume provides an enlightening and pragmatic approach to preserving biological diversity by gathering a wide range of peer-reviewed scientific content from biodiversity researchers and conservators from around the world. It brings comprehensive knowledge and information on the present status of conservation of biological diversity including floral, faunal, and microbial diversity. A detailed account of recent trends in conservation and applications under changing climate conditions, focusing mainly on agriculturally and industrially important microbes and their sustainable utilization, is presented as well. Over the past five decades, extensive research work has been done on many aspects of biodiversity conservation and sustainable utilization of biological resources. This book examines this crucial issue. Chapters discuss biodiversity concepts, benefits, and values for economic and sustainable development; explores applications and strategies for biodiversity preservation; and considers the role of biodiversity conservation in public awareness services and cultural significance. The volume also examines the process of evolution and the future of biodiversity in conjunction with climate change factors, with special reference to infectious diseases. and considers the role of biodiversity conservation in public awareness services and cultural significance. The volume also examines the process of evolution and the future of biodiversity in conjunction with climate change factors, with special reference to infectious diseases.
Data Processing Handbook for Complex Biological Data Sources by
ISBN: 0128165480
Publication Date: 2019-03-28
Data Processing Handbook for Complex Biological Data provides relevant and to the point content for those who need to understand the different types of biological data and the techniques to process and interpret them. The book includes feedback the editor received from students studying at both undergraduate and graduate levels, and from her peers. In order to succeed in data processing for biological data sources, it is necessary to master the type of data and general methods and tools for modern data processing. For instance, many labs follow the path of interdisciplinary studies and get their data validated by several methods. Researchers at those labs may not perform all the techniques themselves, but either in collaboration or through outsourcing, they make use of a range of them, because, in the absence of cross validation using different techniques, the chances for acceptance of an article for publication in high profile journals is weakened.
Essence in the Age of Evolution by
ISBN: 0815375069
Publication Date: 2018-09-20
This book offers a novel defence of a highly contested philosophical position: biological natural kind essentialism. This theory is routinely and explicitly rejected for its purported inability to be explicated in the context of contemporary biological science, and its supposed incompatibility with the process and progress of evolution by natural selection. Christopher J. Austin challenges these objections, and in conjunction with contemporary scientific advancements within the field of evolutionary-developmental biology, the book utilises a contemporary neo-Aristotelian metaphysics of "dispositional properties", or causal powers, to provide a theory of essentialism centred on the developmental architecture of organisms and its role in the evolutionary process. By defending a novel theory of Aristotelian biological natural kind essentialism, Essence in the Age of Evolution represents the fresh and exciting union of cutting-edge philosophical insight and scientific knowledge.
Interreligious Perspectives on Mind Genes and the Self by
ISBN: 1138315753
Publication Date: 2018-10-09
Attitudes towards science, medicine and the body are all profoundly shaped by people's worldviews. When discussing issues of bioethics, religion often plays a major role. In this volume, the role of genetic manipulation and neurotechnology in shaping human identity is examined from multiple religious perspectives. This can help us to understand how religion might affect the impact of the initiatives such as the UNESCO Declaration in Bioethics and Human Rights. The book features bioethics experts from six major religions: Buddhism, Confucianism, Christianity, Islam, Hinduism, and Judaism. It includes a number of distinct religious and cultural views on the anthropological, ethical and social challenges of emerging technologies in the light of human rights and in the context of global bioethics. The contributors work together to explore issues such as: cultural attitudes to gene editing; neuroactive drugs; the interaction between genes and behaviours; the relationship between the soul, the mind and DNA; and how can clinical applications of these technologies benefit the developing world. This is a significant collection, demonstrating how religion and modern technologies relate to one another. It will, therefore, be of great interest to academics working in bioethics, religion and the body, interreligious dialogue, and religion and science, technology and neuroscience.
Understand Your DNA by
ISBN: 9813273259
Publication Date: 2018-09-17
Are you considering to test your own DNA? Do you want to learn more about your health and ancestry? Understand your DNA -- A Guide is about what you can use genetics for. For a few hundred dollars, you can now scan your own genes. Millions of people all over the world have already done so. Everyone wants to see what they can get to know about themselves, and the market growing rapidly. But what does it require from you? And what can you really use a DNA test for? Understand your DNA -- A Guide helps you put the plots and charts of consumer genetics into perspective and enables you to figure out what's up and down in the media headlines. The book is also a key input for today's debate about what we as a society can and want to do with medical genetics. Genetics will play a growing role in the future. Understand your DNA -- A Guide is an easy-to-read and necessary guide to that future. The book is provided with a foreword by Professor Sham Pak-Chung of Hong Kong University. While there are many books about genetics, they typically take the perspective of a scientist wanting to understand the molecular levels. At the same time, direct-to-consumer genetics is a booming market, with millions of people already tested. Very little has been published that will guide them for real, because the need here is more focused on medical and practical understanding, than focussed on molecules. This book therefore aims to hit that vacant spot in the market. It's a walk-through of all concepts that are necessary to understand in your own analysis. Meanwhile, it is also limited in scope to only those concepts -- thus distinguishing it from broader works. The book is appropriate for the readerships in modern multi-ethnic metropolises because it mixes European and Asian examples, both from the collaboration between the author from Europe and the foreword-writer, Prof. Pak Sham of Hong Kong University. But also, because many of the examples in the book concerns differences and similarities between Asian and European ethnicities, something the author believes is a trend in time.
How We Teach Science by
ISBN: 9780674919341
Publication Date: 2019-06-01
A former Wisconsin high school science teacher makes the case that how and why we teach science matters, especially now that its legitimacy is under attack. Why teach science? The answer to that question will determine how it is taught. Yet despite the enduring belief in this country that science should be taught, there has been no enduring consensus about how or why. This is especially true when it comes to teaching scientific process. Nearly all of the basic knowledge we have about the world is rock solid. The science we teach in high schools in particular laws of motion, the structure of the atom, cell division, DNA replication, the universal speed limit of light?is accepted as the way nature works. Everyone also agrees that students and the public more generally should understand the methods used to gain this knowledge. But what exactly is the scientific method? Ever since the late 1800s, scientists and science educators have grappled with that question. Through the years, they've advanced an assortment of strategies, ranging from the laboratory method? to the five-step method? to science as inquiry? to no method at all. How We Teach Science reveals that each strategy was influenced by the intellectual, cultural, and political circumstances of the time. In some eras, learning about experimentation and scientific inquiry was seen to contribute to an individual's intellectual and moral improvement, while in others it was viewed as a way to minimize public interference in institutional science. John Rudolph shows that how we think about and teach science will either sustain or thwart future innovation, and ultimately determine how science is perceived and received by the public.
GUYnecology by
ISBN: 9780520289246
Publication Date: 2020-08-25
What is healthy sperm or the male biological clock? This book details why we don't talk about men's reproductive health and how this lack shapes reproductive politics today. For more than a century, the medical profession has made enormous efforts to understand and treat women's reproductive bodies. But only recently have researchers begun to ask basic questions about how men's health matters for reproductive outcomes, from miscarriage to childhood illness. What explains this gap in knowledge, and what are its consequences? Rene Almeling examines the production, circulation, and reception of biomedical knowledge about men's reproductive health. From a failed nineteenth-century effort to launch a medical specialty called andrology to the contemporary science of paternal effects, there has been a lack of attention to the importance of men's age, health, and exposures. Analyzing historical documents, media messages, and qualitative interviews, GUYnecology demonstrates how this non-knowledge shapes reproductive politics today.
Aquatic Ecosystems in a Changing Climate by
ISBN: 1138350052
Publication Date: 2018-12-17
Global climate change affects productivity and species composition of freshwater and marine aquatic ecosystems by raising temperatures, ocean acidification, excessive solar UV and visible radiation. Effects on bacterioplankton and viruses, phytoplankton and macroalgae have farreaching consequences for primary consumers such as zooplankton, invertebrates and vertebrates, as well as on human consumption of fish, crustaceans and mollusks. It has affected the habitation of the Arctic and Antarctic oceans the most so far. Increasing pollution from terrestrial runoff, industrial, municipal and household wastes as well as marine transportation and plastic debris also affect aquatic ecosystems.
Modeling the 3D Conformation of Genomes by
ISBN: 1138500798
Publication Date: 2019-01-23
This book provides a timely summary of physical modeling approaches applied to biological datasets that describe conformational properties of chromosomes in the cell nucleus. Chapters explain how to convert raw experimental data into 3D conformations, and how to use models to better understand biophysical mechanisms that control chromosome conformation. The coverage ranges from introductory chapters to modeling aspects related to polymer physics, and data-driven models for genomic domains, the entire human genome, epigenome folding, chromosome structure and dynamics, and predicting 3D genome structure.
Attractors and Higher Dimensions in Population and Molecular Biology by
ISBN: 1522596518
Publication Date: 2019-04-26
In studying biology, one of the more difficult factors to predict is how parents' attributes will affect their children and how those children will affect their own children. Organizing and calculating those vast statistics can become extremely tedious without the proper mathematical and reproductive knowledge. Attractors and Higher Dimensions in Population and Molecular Biology: Emerging Research and Opportunities is a collection of innovative research on the methods and applications of population logistics. While highlighting topics including gene analysis, crossbreeding, and reproduction, this book is ideally designed for academics, researchers, biologists, and mathematicians seeking current research on modeling the reproduction process of a biological population.
Computational Biology by
ISBN: 1138587869
Publication Date: 2019-06-18
Computational biology has developed rapidly during the last two decades following the genomic revolution which culminated in the sequencing of the human genome. More than ever it has developed into a field which embraces computational methods from different branches of the exact sciences: pure and applied mathematics, computer science, theoretical physics. This Second Edition provides a solid introduction to the techniques of statistical mechanics for graduate students and researchers in computational biology and biophysics. Material has been reorganized to clarify equilbrium and nonequilibrium aspects of biomolecular systems Content has been expanded, in particular in the treatment of the electrostatic interactions of biomolecules　and the application of non-equilibrium statistical mechanics to biomolecules New network-based approaches for the study of proteins are presented. All treated topics are put firmly in the context of the current research literature, allowing the reader to easily follow an individual path into a specific research field. Exercises and Tasksaccompany the presentations of the topics with the intention of enabling the readers to test their comprehension of the developed basic concepts. p;lt;/P> New network-based approaches for the study of proteins are presented. All treated topics are put firmly in the context of the current research literature, allowing the reader to easily follow an individual path into a specific research field. Exercises and Tasksaccompany the presentations of the topics with the intention of enabling the readers to test their comprehension of the developed basic concepts.
Genomics Data Analysis by
ISBN: 0367280361
Publication Date: 2019-09-18
Statisticians have met the need to test hundreds or thousands of genomics hypotheses simultaneously with novel empirical Bayes methods that combine advantages of traditional Bayesian and frequentist statistics. Techniques for estimating the local false discovery rate assign probabilities of differential gene expression, genetic association, etc. without requiring subjective prior distributions. This book brings these methods to scientists while keeping the mathematics at an elementary level. Readers will learn the fundamental concepts behind local false discovery rates, preparing them to analyze their own genomics data and to critically evaluate published genomics research. Key Features: * dice games and exercises, including one using interactive software, for teaching the concepts in the classroom * examples focusing on gene expression and on genetic association data and briefly covering metabolomics data and proteomics data * gradual introduction to the mathematical equations needed * how to choose between different methods of multiple hypothesis testing * how to convert the output of genomics hypothesis testing software to estimates of local false discovery rates * guidance through the minefield of current criticisms of p values * material on non-Bayesian prior p values and posterior p values not previously published 　
Recent Trends in 'Computational Omics: Concepts and Methodology' by
ISBN: 1536179418
Publication Date: 2020-07-22
The last decade has witnessed various technological advances in life sciences, especially high throughput technologies. These technologies provide a way to perform parallel scientific studies in a very short period of time with low cost. High throughput techniques, mainly, next generation sequencing, microarray and mass spectrometry, have strengthened the omics vision in the last decades (study of complete system) and now resulted in well-developed branches of omics i.e., genomics, transcriptomics, proteomics and metabolomics, which deal with almost every level of central dogma of life. Practice of high throughput techniques throughout the world with different aims and objectives resulted in a voluminous data, which required computational applications, i.e., database, algorithm and software to store, process and get biological interpretation from primary raw data. Researchers from different fields are looking to analyze these raw data for different purposes, but lacking of proper information and knowledge in proper documented form creates different kinds of hurdles and raises the challenges. This book contains thirteen chapters that deal with different computational biology/bioinformatics resources and concepts which are already in practice by the scientific community or can be utilized to handle various aspects of different classes of omics data. It includes different computational concepts, algorithm, resources and recent trends belonging to the four major branches of omics (i.e., genomics, transcriptomics, proteomics and metabolomics), including integrative omics. It will help all scholars who are working in any branch of computational omics and bioinformatics field as well as those who would like to perform research at a systemic biology through computational approaches.
Progress Unchained by
ISBN: 1108842550
Publication Date: 2021-03-04
Progress Unchained reinterprets the history of the idea of progress using parallels between evolutionary biology and changing views of human history. Early concepts of progress in both areas saw it as the ascent of a linear scale of development toward a final goal. The 'chain of being' defined a hierarchy of living things with humans at the head, while social thinkers interpreted history as a development toward a final paradise or utopia. Darwinism reconfigured biological progress as a 'tree of life' with multiple lines of advance not necessarily leading to humans, each driven by the rare innovations that generate entirely new functions. Popular writers such as H. G. Wells used a similar model to depict human progress, with competing technological innovations producing ever-more rapid changes in society. Bowler shows that as the idea of progress has become open-ended and unpredictable, a variety of alternative futures have been imagined.
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